It's hard to imagine that it would, but she could always try. One thing Vista seems to do well is to stop you from installing non-compatible programs. I would guess that it will stop the installation immediately. Of course, the other question is, does she even have a floppy drive on this laptop?
Microsoft does still make <a href="http://www.microsoft.com/products/works/default.mspx" target = blank>MS Works</a>.
But I would also suggest taking a look at <a href="http://www.openoffice.org" target = blank>Open Office</a>, which is a free, open source office suite that she might like even better.
Dale
